pI: 9.8601 |
Length (AA): 242 |
MW (Da): 26363 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
14 | 76 | 1fc6 (A) | 306 | 378 | 40.00 | 0.27 | 0.22 | 0.358631 | 1.66 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128405)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G39460 | S-adenosylmethionine carrier 1 |
Arabidopsis thaliana | AT1G34065 | S-adenosylmethionine carrier 2 |
Brugia malayi | Bm1_57130 | Mitochondrial carrier protein |
Candida albicans | CaO19_7082 | hypothetical protein |
Candida albicans | CaO19.7082 | likely mitochondrial carrier protein similar to S. cerevisiae PET8 (YNL003C) mitochondrial inner membrane S-adenosylmethionine t |
Caenorhabditis elegans | CELE_D1046.3 | Protein D1046.3 |
Cryptosporidium hominis | Chro.60274 | mitochondrial carrier protein |
Cryptosporidium parvum | cgd6_2350 | mitochondrial carrier protein, 4 transmembrane domain |
Drosophila melanogaster | Dmel_CG4743 | CG4743 gene product from transcript CG4743-RA |
Echinococcus granulosus | EgrG_000720700 | S adenosylmethionine mitochondrial carrier |
Echinococcus granulosus | EgrG_000720800 | S adenosylmethionine mitochondrial carrier |
Echinococcus granulosus | EgrG_000720200 | S adenosylmethionine mitochondrial carrier |
Echinococcus multilocularis | EmuJ_000720700 | S adenosylmethionine mitochondrial carrier |
Echinococcus multilocularis | EmuJ_000720200 | S adenosylmethionine mitochondrial carrier |
Echinococcus multilocularis | EmuJ_000720800 | S adenosylmethionine mitochondrial carrier |
Homo sapiens | ENSG00000144741 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 |
Leishmania braziliensis | LbrM.32.0170 | mitochondrial carrier protein, putative |
Leishmania donovani | LdBPK_320110.1 | mitochondrial carrier protein, putative |
Leishmania infantum | LinJ.32.0110 | mitochondrial carrier protein, putative |
Leishmania major | LmjF.32.0110 | mitochondrial carrier protein, putative |
Leishmania mexicana | LmxM.31.0110 | mitochondrial carrier protein, putative |
Loa Loa (eye worm) | LOAG_07771 | hypothetical protein |
Mus musculus | ENSMUSG00000045100 | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 |
Neospora caninum | NCLIV_017590 | Mitochondrial carrier protein-like, related |
Oryza sativa | 4338540 | Os05g0361900 |
Oryza sativa | 4342959 | Os07g0295000 |
Plasmodium berghei | PBANKA_1455000 | mitochondrial carrier protein, putative |
Plasmodium falciparum | PF3D7_1241600 | mitochondrial carrier protein, putative |
Plasmodium knowlesi | PKNH_1460700 | mitochondrial carrier protein, putative |
Plasmodium vivax | PVX_100980 | mitochondrial carrier protein, putative |
Plasmodium yoelii | PY01494 | hypothetical protein |
Saccharomyces cerevisiae | YNL003C | Pet8p |
Schistosoma japonicum | Sjp_0097220 | S-adenosylmethionine mitochondrial carrier protein, putative |
Schistosoma japonicum | Sjp_0306620 | S-adenosylmethionine mitochondrial carrier protein, putative |
Schistosoma mansoni | Smp_044160 | mitochondrial carrier protein |
Schmidtea mediterranea | mk4.004305.00 | S-adenosylmethionine mitochondrial carrier protein |
Trypanosoma brucei gambiense | Tbg972.10.17360 | mitochondrial carrier protein, putative |
Trypanosoma brucei | Tb927.10.14280 | mitochondrial carrier protein |
Trypanosoma congolense | TcIL3000_10_12160 | mitochondrial carrier protein, putative |
Trypanosoma cruzi | TcCLB.511283.124 | mitochondrial carrier protein, putative |
Trypanosoma cruzi | TcCLB.506525.130 | mitochondrial carrier protein, putative |
Toxoplasma gondii | TGME49_242460 | mitochondrial carrier superfamily protein |
Theileria parva | TP03_0431 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14280 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14280 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14280 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.14280 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1455000 | Plasmodium berghei | Essential | plasmo |
TGME49_242460 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.